MINERAL STATUS OF APPARENTLY HEALTHY NORMAL PREGNANT WOMEN AND THEIR NEONATES AT PARTUBITION

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Date
1992-05
Authors
DANLADI, ICCE
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Abstract
The mineral s t a t u s , hematologic and socioeconomic s t a t u s of 55 a p p a r e n t l y h e a l t hy prurient mothers resident in Northern Nigeria and t h e i r neonates were evaluated. The mineral status of 20 apparently healthy non-pregnant women of c h i l d - b e a r i n g age who served as the c o n t r ol subjects were simultaneously determined. Their mineral status was evaluated by measuring the serum concentrations of 5 trace and 2 macro-elements namely Fe,Cu,Zn,Mn,Cr and Ca Mg respectively while Hb and PCV served as the hematological parameters evaluated. Base-line data from the present study indicate that with the exception of Ca and Cu, the control subjects had adequate mineral s t a t u s/ Although the parturient women had lower (p<0.05) Hb and PCV indices than the control subjects, it is evident from the study that mineral levels are in creased following pregnancy. The mean serum Fe, Cu and Ca concentrations of the control subjects were 82.00 ± 23.30, 6.67 + 4.88 ug\100ml and 8.62 ± 2.75 mg\100ml respectively while the maternal mean serum levels for the same elements were 149.18 ± 54.87, 125.47 ± 113.20 JJg/100ml. viii and 11.90 + 3.30 mg/1OOml respectively. Fetal Fe, Cu and Ca levels were also 194.73 + 104.67, 110.32 ± 86.69 ug/1OOml and 12.3 + 3.98mg\100ml respecively. Regression analysis revealed significant (P< 0.05) positive association between Cu and Zn(r=o.713), and Zn and Mn(r=0.522) in the control Subjects. Age and Mg, Cu and Mn and PCV and Mg bore a converse correlation in the maternal serum. With the Exception of Fe which bore a negative correlation, the maternal - fetal mineral interrelationships were positive for each element suggesting that maternal circulation is the main fetal source of the elements. Maternal age, Parity, hematologic and socioeconomic status had no significant (P>0.05) effect on the fetal mineral status. The various interrelationships evident between the numerous parameters in the present study are discussed
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A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, DEPARTMENT OF BIOCHEMISTRY, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE MASTER OF SCIENCE DEGREE IN BIOCHEMISTRY MAY, 1992
Keywords
MINERAL,, STATUS,, APPARENTLY,, HEALTHY,, NORMAL,, PREGNANT,, PREGNANT,, WOMEN,, NEONATES,, PARTUBITION
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