SYNTHESIS AND ANTICONVULSANT SCREENING OF THREE ISOMERIC 3-(DIMETHYLPHENYL)AMINOPROPANAMIDES
SYNTHESIS AND ANTICONVULSANT SCREENING OF THREE ISOMERIC 3-(DIMETHYLPHENYL)AMINOPROPANAMIDES
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Date
2014-09
Authors
AHMAD, SHUAIBU
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Abstract
Tremendous effort was made in this work to synthesize the three isomeric 3-
(dimethylphenyl)aminopropanamides through the Michael nucleophilic substitution reaction.
However, some of the results obtained after spectroscopic analysis did not satisfactorily conform
to the structure of the compounds, this was attributed perhaps to the lack of control of the
experimental conditions, the methodology adopted or some instrumental constrains. The
anticonvulsant screening of the hypothetical compounds was also carried out via the maximal
electroshock (MES) and pentylenetetrazole seizure models.
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SYNTHESIS AND ANTICONVULSANT, ISOMERIC 3-(DIMETHYLPHENYL)AMINOPROPANAMIDES