EFFECT OF AQUEOUS EXTRACT OF THE BARK OF KHA YA SENEGALENSIS ON PHENYLHYDRAZINE INDUCED ANAEMIA
EFFECT OF AQUEOUS EXTRACT OF THE BARK OF KHA YA SENEGALENSIS ON PHENYLHYDRAZINE INDUCED ANAEMIA
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Date
1998-05
Authors
IBRAHIM, FATIMAH OZIOHU
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Abstract
Phytochcmical screening was conducted using petroleum ether (40 - 60°C),
melhanolic and aqueous extract of the stem bark. Both the methanolic and aqueous
extracts gave positive result to carbohydrates, saponin glycosides and tannins. In addition,
terpenes and anthraquinoncs were found only in the methanolic extract. The petroleum
ether extract contained only steroids. Data on the mineral content of the aqueous extract
of the bark showed that it is rich in some of the important mineral element needed for the
development and functioning of blood. Trial experiment to determine the suitable dose of
phcnylhydrazine for induction of anaemia in rats showed that 750mg/kg body weight
would give a suitable anaemic condition. /// vivo investigation of the effect of oral daily
dose (300mg/kg body weight) of the bark aqueous extract on phcnylhydrazine - induced
anaemia in rats did not show any significant curative effect (P > 0.001). However, the
same oral dosage seemed to produce significant (P < 0.001) Prophylaltic effect probably
by protecting the red blood cell against Phcnylhydrazine destruction. Subcutaneous
injection of 30mg/kg body weight on Trypanosoma brucei induced anaemia in the rats did
not produce anaemia or trypanocidal effect.
Description
A Thesis submitted to the Postgraduate School, Ahmadu Bello University, Zaria in Partial
fulfillment of the requirements for the degree of Master of Science in Biochemistry.
Department of Biochemistry
Faculty of Science,
Ahmadu Bello University, Zaria
Keywords
EFFECT,, AQUEOUS EXTRACT,, BARK,, KHA YA,, SENEGALENSIS,, PHENYLHYDRAZINE,, INDUCED,, ANAEMIA