COMPARATIVE STUDIES ON THE INEFECTIVITY AND PATHOGENICITY OF EXPERIMENTAL TRYPANOSOMA BRUCEI BRUCEI INFECTION IN MICE, RATS, RABBITS AND GUINEA FOWLS

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dc.contributor.authorHUSSAIN, KARIMAT
dc.date.accessioned2021-07-12T09:16:09Z
dc.date.available2021-07-12T09:16:09Z
dc.date.issued2018-01
dc.descriptionA THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES, AHMADU BELLO UNIVERSITY ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTER OF SCIENCE IN VETERINARY PROTOZOOLOGY DEPARTMENT OF VETERINARY PARASITOLOGY AND ENTOMOLOGY, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIAen_US
dc.description.abstractThe study compared the infectivity and pathogenecity of experimental Trypanosoma brucei brucei infection in mice, rats, rabbits and guinea fowls. A total of 10 each of the following animals‟ mice, rats, rabbits and guinea fowls of both sexes were used for the study. Each group of the animal species was divided into two groups (infected and control) of five animals each. The mice, rats, rabbits and guinea fowls in the infected groups were individually inoculated with blood containing 1 x106 Trypanosoma brucei brucei (Fadere stock). All animals in the control groups were not infected. Patent parasitaemia as determined by haematocrit centrifugation technique was between 3-4 days in the mice and rats, while it was 7-8 days in rabbits. No parasitaemia was seen in the infected Guinea fowl throughout the study. The mean body weights of mice, rats and rabbits decreased in the infected group as compared to the control group. All animals in the infected group with the exception of guinea fowls showed increase in body temperature. In the mice and rats there were significance diferrences (SD) (p < 0.05) in the overall mean PCV, HGB and RBC between the infected groups (IG) as compared to the control group (CG). In the rabbits there were SSD (P < 0.05) in the overall mean PCV, HGB and RBC between the IG (36.1 ± 0.6%, 12.11 ± 0.8 g/dl and 5.9 ± 0.4×106) and CG (43.7 ± 0.5%, 14.1 ± 0.9 g/dl and 7.23 ± 0.3×106 respectively). There was no SD (P > 0.05) between the overall mean PCV, HGB and RBC of the infected guinea fowls and those of the control group throughout the period of the experiment. Also, no mortality was recorded among the infected guinea fowls as consequence of the infection. A decrease in mean total white blood cell (WBC) counts of the rats and the rabbits were observed while mice and guinea fowls groups showed no significance difference between the WBC of the infected and control groups. Microscopic lesions observed in the mice, rats and rabbits included congested central vein and perivascular cuffing, congestion and mononuclear cellular infilteration around blood vessels of the lungs, depletion of lymphoid cells, congested inter tubular spaces and focal necrosis of renal tubular epithelium. In the guinea fowls, the spleen revealed heamosiderosis. The study thus demonstrated that mice, rats and rabbits are, in order of susceptibility better laboratory models than the guinea fowls which tend to show some measure of resistance to Trypanosoma brucei brucei used in the experiment. Therefore rabbits could be use in our laboratory to preserve Trypanosoma brucei brucei.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/12464
dc.language.isoenen_US
dc.subjectCOMPARATIVE STUDIES ON THE INFECTIVITY,en_US
dc.subjectPATHOGENICITY,en_US
dc.subjectEXPERIMENTAL TRYPANOSOMA BRUCEI BRUCEI INFECTION,en_US
dc.subjectMICE, RATS, RABBITS,en_US
dc.subjectGUINEA FOWLSen_US
dc.titleCOMPARATIVE STUDIES ON THE INEFECTIVITY AND PATHOGENICITY OF EXPERIMENTAL TRYPANOSOMA BRUCEI BRUCEI INFECTION IN MICE, RATS, RABBITS AND GUINEA FOWLSen_US
dc.typeThesisen_US
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