EFFECT OF TAMARINDUS INDICA AND SODIUM/POTASSIUM HAUSA SALT ON THE BIOAVAILABILITY OF ASPIRIN IN MAN

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Date
1991-12
Authors
ADAMU, YAKASAI IBRAHIM
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Abstract
Aspirin and salicylic acid powders and aspirin tablets identification tests were carried out following B.P. (1980) specifications. The results obtained were in conformity with the official book specifications under identification tests for aspirin and salicylic acid. Volumetric method of chemical assay B.P. (1988) were employed to determine the total drug content for aspirin and salicylic acid powders and aspirin tablets. The results compared favourably with the stated amount in the B.P. (1988). Dissolution rate profile for the two brands of aspirin tablets (Polfa and Vitalink) in 0.1M HC1 was investigated by means of B.P. (1988) rotating basket method. Total drug release of the active ingredient for the two brands was obtained in less than 45 minutes. Disintegration time test was carried out on the two brands of aspirin tablets. There was no considerable variation in their disintegration time. The times taken for the two brands to disintegrate was less than 5 minutes. They all passed the official requirement of 15 minutes for tablet disintegration. In-vivo bioavailability studies were carried out in six healthy human volunteers under four conditions. Each volunteer ingested 600mg aspirin only; then with starch; with Tamarindus indica extract (Tsamiya) and also with sodium/potassium Hausa salt extract (Kanwa) all in the form of Hausa food drink Kunu. A simple, rapid and accurate method for the determination of plasma and saliva aspirin and salicylic acid levels by multiple component spectrophotometry method was employed. Also employed in the analysis was HPLC method. Because of the reliability, accuracy and sensitivity of HPLC, it was used as a standard in comparing the results got from U.V. spectrophotometry method. Pharmacokinetic parameters for plasma and saliva aspirin and salicylic acid samples were generated by computer application. Statistical analysis of the results showed, however, that concurrent ingestion of aspirin with T. indica extract gave rise to a significant increase (P<0.01) in the amount of drug absorbed compared with the fasting state. Also concurrent administration of the drug with sodium/potassium Hausa salt extract gave rise to a significant decrease in the amount of drug absorbed (P<0.05) compared with the fasting state. Hence, it can be concluded that the bioavailability of aspirin is enhanced by T. indica and diminished by sodium/potassium salt in man.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN PHARMACEUTICAL CHEMISTRY DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY, FACULTY OF PHARMACEUTICAL SCIENCES, AHMADU BELLO UNIVERSITY, ZARIA, NIGERIA
Keywords
EFFECT,, TAMARINDUS INDICA,, SODIUM/POTASSIUM
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