EFFECT OF TAMARINDUS INDICA AND SODIUM/POTASSIUM HAUSA SALT ON THE BIOAVAILABILITY OF ASPIRIN IN MAN
EFFECT OF TAMARINDUS INDICA AND SODIUM/POTASSIUM HAUSA SALT ON THE BIOAVAILABILITY OF ASPIRIN IN MAN
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Date
1991-12
Authors
ADAMU, YAKASAI IBRAHIM
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Abstract
Aspirin and salicylic acid powders and aspirin
tablets identification tests were carried out following
B.P. (1980) specifications. The results obtained were
in conformity with the official book specifications
under identification tests for aspirin and salicylic
acid.
Volumetric method of chemical assay B.P. (1988)
were employed to determine the total drug content for
aspirin and salicylic acid powders and aspirin tablets.
The results compared favourably with the stated amount
in the B.P. (1988).
Dissolution rate profile for the two brands of
aspirin tablets (Polfa and Vitalink) in 0.1M HC1 was
investigated by means of B.P. (1988) rotating basket
method. Total drug release of the active ingredient
for the two brands was obtained in less than 45 minutes.
Disintegration time test was carried out on the
two brands of aspirin tablets. There was no considerable
variation in their disintegration time. The times taken
for the two brands to disintegrate was less than 5
minutes. They all passed the official requirement of
15 minutes for tablet disintegration.
In-vivo bioavailability studies were carried out
in six healthy human volunteers under four conditions.
Each volunteer ingested 600mg aspirin only; then with
starch; with Tamarindus indica extract (Tsamiya) and
also with sodium/potassium Hausa salt extract (Kanwa)
all in the form of Hausa food drink Kunu.
A simple, rapid and accurate method for the
determination of plasma and saliva aspirin and
salicylic acid levels by multiple component spectrophotometry
method was employed. Also employed in the
analysis was HPLC method. Because of the reliability,
accuracy and sensitivity of HPLC, it was used as a
standard in comparing the results got from U.V.
spectrophotometry method.
Pharmacokinetic parameters for plasma and saliva
aspirin and salicylic acid samples were generated by
computer application.
Statistical analysis of the results showed,
however, that concurrent ingestion of aspirin with
T. indica extract gave rise to a significant increase
(P<0.01) in the amount of drug absorbed compared with
the fasting state. Also concurrent administration of
the drug with sodium/potassium Hausa salt extract gave
rise to a significant decrease in the amount of drug
absorbed (P<0.05) compared with the fasting state.
Hence, it can be concluded that the bioavailability
of aspirin is enhanced by T. indica and diminished by
sodium/potassium salt in man.
Description
A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL,
AHMADU BELLO UNIVERSITY, ZARIA IN PARTIAL
FULFILLMENT OF THE REQUIREMENTS FOR THE
AWARD OF THE DEGREE OF MASTER OF
SCIENCE IN PHARMACEUTICAL CHEMISTRY
DEPARTMENT OF PHARMACEUTICAL AND MEDICINAL CHEMISTRY,
FACULTY OF PHARMACEUTICAL SCIENCES,
AHMADU BELLO UNIVERSITY,
ZARIA, NIGERIA
Keywords
EFFECT,, TAMARINDUS INDICA,, SODIUM/POTASSIUM