PHARMACOGNOSTIC FEATURES AND ANTIMICROBIAL ACTIVITY OF MITRACARPUS VILLOSUS (SW), DC (Family: RUBIACEAE)
PHARMACOGNOSTIC FEATURES AND ANTIMICROBIAL ACTIVITY OF MITRACARPUS VILLOSUS (SW), DC (Family: RUBIACEAE)
| dc.contributor.author | ANDREW, G. ONYILOYI | |
| dc.date.accessioned | 2014-02-03T09:36:11Z | |
| dc.date.available | 2014-02-03T09:36:11Z | |
| dc.date.issued | 1999-04 | |
| dc.description | A THESIS SUBMITTED TO THE POSTGRADUATE SCHOOL, AHMADU BELLO UNIVERSITY, ZARIA, IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF SCIENCE IN PHARMACOGNOSY DEPARTMENT OF PHARMACOGNOSY AND DRUG DEVELOPMENT FACULTY OF PHARMACEUTICAL SCIENCES AHMADU BELLO UNIVERSITY ZARIA - NIGERIA | en_US |
| dc.description.abstract | The medicinal plant, Mitracarpus villosus (SW) DC, formerly (Mitracarpus scaber Zuccarl, family; Rubiaceae is a herb, occurring in both the Savannah and the Forest Zones (Wickens, 1976). Microscopical examinations of the fresh as well as the powdered root, stem, and leaves of M. villosus were carried out and characteristic features like calcium oxalate crystals and paracytic stomata are noted. Chemomicroscopy of the root, stem, leaves and inflorescence of M. villosus revealed the presence of lignins, anthraquinones, oil droplets, starch and clusters of calcium oxalate crystals, while the preliminary phytochemical tests showed the presence of alkaloids, carbohydrate (sugars), flavonoids, saponins and tannins. Paper and thin layer chromatographic analyses carried out also confirmed the presence of some of these constituents. Alkaloids were detected and tentatively assigned to the (phenanthrene type) group. Extracts of the entire plant in different solvents exhibited antimicrobial activity against standard cultures of B^ subtilis (NCTC 8236) , E. coli (NCTC 10418) , Proteus vulgaris, Pseudomonas aeruginosa (NCTC 67 50), Staphylococcus aureus (NCTC 6571), Streptococcus pyogenes (NCTC 8189) and Candida albicans (standard). The activity of the hot water extract of the entire plant was higher than those of the cold water/alcohol extracts on all test organisms. Extracts of the Unrefined secondary metabolites of the plant showed activity against both Gram negative and positive organisms. The Gram positive organisms were slightly more susceptable. The rate at which B. subtilis (NCTC 8236), and Streptococcus pyogenes (NCTC 8198), were killed by extracts (alkaloids and steroids) were also tested. The rates of kill were comparable. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/60 | |
| dc.language.iso | en | en_US |
| dc.subject | PHARMACOGNOSTIC, | en_US |
| dc.subject | FEATURES, | en_US |
| dc.subject | ANTIMICROBIAL, | en_US |
| dc.subject | ACTIVITY, | en_US |
| dc.subject | MITRACARPUS VILLOSUS | en_US |
| dc.title | PHARMACOGNOSTIC FEATURES AND ANTIMICROBIAL ACTIVITY OF MITRACARPUS VILLOSUS (SW), DC (Family: RUBIACEAE) | en_US |
| dc.type | Thesis | en_US |