COMPARATIVE EFFECTS OF HYDROCORTISONE, DEXAMETHASONE AND METHYLPREDNISOLONE ON HEALING OF EXPERIMENTAL CANINE WOUNDS MANAGED CLINICALLY.
COMPARATIVE EFFECTS OF HYDROCORTISONE, DEXAMETHASONE AND METHYLPREDNISOLONE ON HEALING OF EXPERIMENTAL CANINE WOUNDS MANAGED CLINICALLY.
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Date
2011-03
Authors
JAPHETH, Joel Kalang
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Abstract
Twelve dogs divided into four groups of three each were screened to determine the effects of corticosteroids on experimentally created surgical wounds. Under general aneasthesia and using standard technique, 2 × 3 cm and 5 cm excisional and incisional wounds were created respectively on either side of the dorsum of experimental dogs. Dogs in groups I served as the control, group II had hydrocortisone (1mg/kg IM), group III had dexamethasone (0.5 milligram (mg)/kg IM) and group IV had methylprednisolone (1mg/kg IM). Dogs were treated for 5 days post surgery. Heparinized blood samples were routinely taken. Biopsies of surgical wounds were taken on days 3, 7, 14, 18 and 21 post-surgery and studied histopathologically. Grossly wound contraction in control group I dogs was comparable to that in group II dogs that had hydrocortisone in excisional wounds. For incisional wounds dogs in control group I had best contraction. Inflammatory reaction was abundant in the control group I dogs and least in group IV dogs that had methylprednisolone. Scar tissue formation was best in group IV dogs that had methylprednisolone, although the difference was of no statistical significance. It was concluded that; methylprednisolone had the best arrangement of arrangement of collagen, early epithelialisation and the thinnest scar. This could be recommended for facial, ocular and other cosmetic surgery; dexamethasolone produced the thickest scar and therefore could be recommended for use in wounds where high strength is required like herniorraphy and; dexamethasone and methylprednisolone-treated dogs showed absence of itching during wound healing when compared to the control and hydrocortisone-treated dogs. Moreso, clinical use of corticosteroids in the management of surgical wound had no significant effect on the quality of healing.
Finally, investigations are needed at the molecular and micromolecular levels to acertain the effects of these steroids on the quality of wound healing.
Description
A THESIS SUBMITTED TO THE SCHOOL OF POSTGRADUATE STUDIES AHMADU BELLO UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTER OF SCIENCE IN VETERINARY SOFT-TISSUE SURGERY
DEPARTMENT OF VETERINARY SURGERY AND MEDICINE,
FACULTY OF VETERINARY MEDICINE,
AHMADU BELLO UNIVERSITY,
ZARIA
Keywords
COMPARATIVE EFFECTS OF HYDROCORTISONE,, DEXAMETHASONE,, METHYLPREDNISOLONE ON HEALING,, EXPERIMENTAL CANINE WOUNDS MANAGED CLINICALLY.