TABLETING BEHAVIOUR OF SOME DEPOLYMERIZED LOCAL STARCHES
TABLETING BEHAVIOUR OF SOME DEPOLYMERIZED LOCAL STARCHES
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Date
1995-02
Authors
LINUS, AGBO JOSEPH
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Abstract
Starches extracted from millet, sorghum and yam were
subjected to various degrees of hydrolysis. Investigations showed
that the starch particles remained superficially unchanged but
microscopic examination revealed a tendency of the particles to be
more regularly shaped and there was a gradual reduction of average
particle size with increasing depolymerization. It was also shown
that hydrolysis generally improved the flow of all starch
specimens, except for modified millet starch (MMS) which
exhibited an initial increase in flow followed by a reduction with
increase degree of depolymerization.
In an evaluation of the compressibility of the starches in
relation to degree of hydrolysis, it was observed that acid
modification improved compressibility of all starch samples, and
that with increased hydrolysis, there was improved
compressibility. Compressibility as determined by tablets'
hardness and density shows MMS to be the most compressible
followed by modified sorghum starch (MSS) and modified yam
starch (MYS) respectively. Microcrystalline cellulose (MCC)
compressed better than all the modified starches but tablets made
from products of the highest degree of starch hydrolysis had very
good physical properties comparable to those made from MCC. All
the parent starches were unable to form coherent tablets even at
very high compression pressure settings. Using the modified
starches as direct compression filler-binder-disintegrant in a
Trimethoprim tablet formula, tablets with greater hardness and
density values were obtained and were less friable compared to
tablets of the modified starches alone.
A study of the compactional behaviour of physical mixtures
of the modified starches with MCC and with Starch 1500
respectively indicated better flowability for all the modified
starches irrespective of starch type or mixture composition
compared to the modified starches alone. The binary mixtures with
MCC flowed better than those with Starch 1500. Increasing the
proportion of modified starch in the mixtures resulted in reduced
flow. MYS mixtures compacted best at all proportions of mixing.
In a comparative study of the properties of tablets from
the unmodified starches and their hydrolysed forms as fillers
respectively in wet granulation tableting, it was found that flow
of the granules made from starch in their unmodified forms was
lower than those from the modified starches. Compared to the
direct compression tableting, very low compression forces were
required to compact the granules to produce tablets with good
physical properties. In addition, tablets made from modified
starches as fillers possessed better tablet properties than those
from their parent forms.
Description
A Thesis Submitted to the Postgraduate School
Ahmadu Bello University, ZARIA
In Partial Fulfillment of the Requirements for the Award of the
Degree of Master of Science in Pharmaceutics
Department of Pharmaceutics and
Pharmaceutical Microbiology,
Faculty of Pharmaceutical Sciences,
Ahmadu Bello University,
Zaria, NIGERIA
FEBRUARY, 1995
Keywords
TABLETING,, BEHAVIOUR,, DEPOLYMERIZED,, LOCAL,, STARCHES.