EVALUATION OF MILLET STARCHES (Pennisetum glaucum and Pennisetum americanum) AS TABLET BINDERS AND DISINTEGRANTS
EVALUATION OF MILLET STARCHES (Pennisetum glaucum and Pennisetum americanum) AS TABLET BINDERS AND DISINTEGRANTS
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Date
2011-05
Authors
YAKUBU, AMODU
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Abstract
Starch was extracted from the two varieties of millet (Pennisetum glaucum and
Pennisetum americanum) by the wet extraction method, the percentage yield was
determined. The physicochemical properties investigated includes: flow rate, angle of
repose, carr’s index, tapped density, bulk density, moisture content, swelling capacity,
particle size, solubility, iodine test, and hausner ratio. Granules were prepared by the wet
granulation method of massing and screening using the two varieties of millet starches as
disintegrants and binders in one formulation and comparing their physicochemical
properties with that of maize starch BP.
Paracetamol tablets were formulated using Pennisetum glaucum and Pennisetum
americanum starch as binder and disintegrant compared with maize starch and
studying the tableting properties of the tablets produced.
The percentage yields of starch from the two varieties of millet were found to be 50%
for Pennisetum glaucum and 56.8% for Pennisetum americanum. The two starches have
similar flow, swelling, power and moisture sorption properties. The suitability of millet
starches as binders and disintegrants at various concentrations were investigated in
tablet formulations using paracetamol as the medicinal substances. The millet
starches (Pennisetum glaucum and Pennisetum americanum) formulations were
compared for hardness, friability, disintegration time against maize starch
formulations. Using the same concentrations of binders and disintegrants. The results
indicated that millet starches were suitable binders and Disintegrants. When the
disintegrant and binding properties were analysed and compared with maize starch
There was an increase in tablet crushing strength as the disintegrant concentration
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increased. There was also a decrease in the friability of the tablets as binder
concentration increased. Disintegration time was found to increase with increase in
binder concentration.
Description
THESIS SUBMITTED TO THE POSTGRAGUATE SCHOOL,AHMADU
BELLO UNIVERSITY, ZARIA, IN PARTIAL FULFILMENT FOR THE
AWARD OF THE DEGREE OF MASTER OF SCIENCE IN
PHARMACEUTICS.
DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL
MICROBIOLOGY, FACULTY OF PHARMACEUTICAL SCIENCES,
AHMADU BELLO UNIVERSITY, ZARIA-NIGERIA
Keywords
EVALUATION OF MILLET STARCHES,, TABLET BINDERS,, DISINTEGRANTS